Mazdutide

Buy Mazdutide at Pepcore: Mazdutide as lyophilized powder (10 mg), ≥99% HPLC purity, dispatched from the Netherlands the same business day. Mazdutide is a lab-made peptide that works on two targets at once: the GLP-1 receptor and the glucagon receptor. It is best known in research for the way it engages both of these pathways together, which is what sets it apart from peptides that hit only one.

Buy Mazdutide: key facts

• Available amounts: 10 mg
• Purity: ≥99% by HPLC – certificate of analysis (HPLC and MS) on request
• Form: Lyophilized powder
• Price: from €119.00
• Dispatch: same business day from the Netherlands when paid before 14:00 CET (Mon–Sat)
• Shipping: tracked across Europe – free from €250
• Payment: SEPA bank transfer or crypto (USDC, USDT, Bitcoin)

Mazdutide at a glance

It also has a growing research base, with work looking at how its dual-receptor action plays out in metabolic studies (Ji et al., 2022, eClinicalMedicine). That makes it a useful tool compound for this kind of laboratory work.

Research Applications

• Incretin-pathway research models
• GLP-1 receptor signaling studies
• Glucagon receptor research
• Energy-metabolism laboratory work

Supplied as a lyophilized powder for stability.

What is Mazdutide?

Mazdutide (also referenced in research literature as IBI362 and LY3305677) is a synthetic dual receptor agonist research peptide engineered as an analog of oxyntomodulin, a proglucagon-derived endogenous hormone that engages both the GLP-1 receptor and the glucagon receptor. The mazdutide scaffold incorporates a fatty-acid side chain that extends the molecule's pharmacokinetic profile.

The rationale behind oxyntomodulin-analog research is that combined GLP-1 and glucagon receptor signaling may modulate energy-metabolism research models through complementary pathways. GLP-1 receptor activity is investigated for its association with glucose-signaling research and central neuroendocrine pathways relevant to energy-balance research. Glucagon receptor activity is investigated for its association with hepatic lipid-metabolism research and energy-expenditure research models.

This positioning at the intersection of two established proglucagon-derived receptor systems has made mazdutide an experimental research compound of considerable interest in laboratory research studies of dual agonist receptor pharmacology, receptor-balance signaling, and integrated metabolic-pathway research.

Mazdutide: structure and specifications

Mazdutide in laboratory research

GLP-1 Receptor Engagement

Mazdutide engages the GLP-1 receptor, a class B G-protein-coupled receptor expressed across pancreatic, central, and peripheral tissues in research models. GLP-1 receptor signaling research is associated with glucose-dependent insulin-signaling pathways and central neuroendocrine modulation relevant to energy-balance research.

Glucagon Receptor Engagement

Mazdutide also engages the glucagon receptor, which is expressed across hepatic and adipose research tissues. Glucagon receptor signaling is investigated in laboratory research studies for its association with hepatic glucose-output research, lipid-metabolism research, and energy-expenditure research models.

Oxyntomodulin-Pathway Mimicry

Because mazdutide is engineered as an oxyntomodulin analog, it mirrors the endogenous dual receptor engagement profile of proglucagon-derived hormones. Structural-pharmacology research has characterized how mazdutide interacts with GLP-1 and glucagon receptors through molecular docking and receptor-binding research models (Zhang et al., 2025).

Integrated Dual Agonist Signaling

By interacting with both receptor systems within a single molecule, mazdutide is investigated as a tool for studying receptor-balance pharmacology, downstream signaling crosstalk, and integrated metabolic-pathway adaptation in research models. The fatty-acid acylation extends the half-life of the molecule, supporting receptor-pharmacology research at extended timepoints.

Conclusion

Mazdutide represents an experimental research compound class of oxyntomodulin-analog dual receptor agonists that engage GLP-1 and glucagon receptors simultaneously. By integrating two proglucagon-derived receptor arms within a single peptide, mazdutide supports laboratory research studies of receptor-balance pharmacology and integrated metabolic-pathway signaling, making it a valuable research target for investigations of dual agonist receptor pharmacology and energy-metabolism research models.

Reconstitution and storage

Mazdutide is supplied as a lyophilized powder in a sealed glass vial. In the laboratory it is reconstituted with bacteriostatic water, added slowly down the inside of the vial and swirled gently until dissolved – never shaken. Our peptide calculator works out the concentration for your vial size, and the reconstitution guide explains each step.

Keep unopened vials cool, dry and away from light – frozen at −20 °C for long-term storage. Once reconstituted, keep the solution at 2–8 °C; our peptide stability guide lists typical shelf lives.

Buy Mazdutide from Pepcore: shipping and payment

Orders paid before 14:00 CET (Monday–Saturday) leave our Netherlands warehouse the same business day in discreet, tracked packaging. Delivery takes 1–2 business days to the Netherlands and Belgium, 2–7 to Germany, France, Spain, Italy and Luxembourg and 3–8 to the rest of the EU; the UK, Switzerland and Norway take 5–10 days plus customs. Shipping costs from €8.49 and is free from €250 – see our shipping policy.

When you buy Mazdutide at Pepcore you pay by SEPA bank transfer – we email you our bank details right after your order – or with crypto: USDC or USDT on Polygon, USDC on Base, or Bitcoin. No customer account and no card details are needed.

Frequently asked questions

Scientific references

• Ji L et al. (2022). Safety and efficacy of a GLP-1 and glucagon receptor dual agonist mazdutide (IBI362) 9 mg and 10 mg in Chinese adults with overweight or obesity: A randomised, placebo-controlled, multiple-ascending-dose phase 1b trial. eClinicalMedicine. PubMed
• Dong W et al. (2025). Mazdutide, a dual agonist targeting GLP-1R and GCGR, mitigates diabetes-associated cognitive dysfunction: mechanistic insights from multi-omics analysis. eBioMedicine. PubMed
• Bhattachar SN et al. (2025). Mazdutide reduces body weight in adults with overweight or obesity: A high-dose Phase 1 trial. Diabetes, Obesity & Metabolism. PubMed
• Pocai A (2014). Action and therapeutic potential of oxyntomodulin. Molecular Metabolism. PubMed

More studies: PubMed: Mazdutide

Ready to buy Mazdutide? Choose your amount above – orders paid before 14:00 CET ship the same day, and shipping is free from €250. For questions about Mazdutide or a larger research order, write to us at info@pepcore.net.