PEG-MGF

Buy PEG-MGF at Pepcore: PEG-MGF as lyophilized powder (2 mg), ≥99% HPLC purity, dispatched from the Netherlands the same business day. PEG-MGF is Mechano Growth Factor with a PEG chain attached, which makes the peptide last much longer in research models than plain MGF. It carries the same muscle repair signal that activates satellite cells after training or injury, so it is used in muscle regeneration, hypertrophy and recovery research where a longer-acting form is needed.

Buy PEG-MGF: key facts

• Available amounts: 2 mg
• Purity: ≥99% by HPLC – certificate of analysis (HPLC and MS) on request
• Form: Lyophilized powder
• Price: from €69.00
• Dispatch: same business day from the Netherlands when paid before 14:00 CET (Mon–Sat)
• Shipping: tracked across Europe – free from €250
• Payment: SEPA bank transfer or crypto (USDC, USDT, Bitcoin)

PEG-MGF at a glance

PEG-MGF is studied for the same E-domain signal as MGF: work in myoblasts shows it drives muscle-cell proliferation through a route separate from mature IGF-1 (Yang et al., 2002, FEBS Letters).

Research Applications

• Studied in muscle regeneration and repair models
• Relevant in research on satellite-cell activation and hypertrophy
• Examined in long-acting peptide and half-life studies
• Applied in neuronal and cardiac tissue-protection work

Supplied as a lyophilized powder for stability.

What is PEG-MGF?

Skeletal muscle repair depends on satellite cells, the resident stem cells that proliferate and fuse into damaged fibres after mechanical stress. The IGF-1 gene responds to loading by alternative splicing, producing the IGF-1Ec isoform whose C-terminal E-domain, known as Mechano Growth Factor (MGF), is expressed within hours of injury and precedes the systemic IGF-1 response.

The native E-peptide is short-lived in solution, which complicates work on its independent signaling. PEG-MGF addresses this by conjugating a polyethylene glycol chain to the synthetic peptide, extending its half-life in research models while preserving the sequence responsible for satellite cell activation.

This makes PEG-MGF a practical tool for laboratory work on muscle regeneration, myoblast kinetics, and the tissue-protective actions of the E-domain reported in cardiac and neuronal models.

PEG-MGF: structure and specifications

PEG-MGF in laboratory research

Satellite Cell Activation

The MGF E-domain signals resident muscle satellite cells to leave quiescence and enter the cell cycle, expanding the pool of progenitors available for fibre repair in research models.

Proliferation Distinct From Mature IGF-1

Studies in C2C12 myoblasts show the E-peptide increases proliferation while delaying terminal differentiation, an effect not blocked by IGF-1 receptor antibodies, pointing to a signaling route separate from mature IGF-1.

Extended Exposure Through PEGylation

The polyethylene glycol chain shields the peptide from rapid clearance and enzymatic breakdown, extending its half-life so that the E-domain remains available to tissue for a longer period in experimental systems.

Tissue-Protective Signaling

Beyond muscle, the E-peptide has been reported to reduce neuronal loss in brain ischemia models and to preserve cardiac function in experimental infarction models, indicating conserved protective signaling across tissues.

Conclusion

PEG-MGF is a stabilized research form of Mechano Growth Factor that lets investigators study the E-domain's contribution to satellite cell activation, myoblast proliferation, and tissue repair over a longer window than the native peptide allows. It is a versatile tool for regeneration, hypertrophy, and tissue-protection research.

Reconstitution and storage

PEG-MGF is supplied as a lyophilized powder in a sealed glass vial. In the laboratory it is reconstituted with bacteriostatic water, added slowly down the inside of the vial and swirled gently until dissolved – never shaken. Our peptide calculator works out the concentration for your vial size, and the reconstitution guide explains each step.

Keep unopened vials cool, dry and away from light – frozen at −20 °C for long-term storage. Once reconstituted, keep the solution at 2–8 °C; our peptide stability guide lists typical shelf lives.

Buy PEG-MGF from Pepcore: shipping and payment

Orders paid before 14:00 CET (Monday–Saturday) leave our Netherlands warehouse the same business day in discreet, tracked packaging. Delivery takes 1–2 business days to the Netherlands and Belgium, 2–7 to Germany, France, Spain, Italy and Luxembourg and 3–8 to the rest of the EU; the UK, Switzerland and Norway take 5–10 days plus customs. Shipping costs from €8.49 and is free from €250 – see our shipping policy.

When you buy PEG-MGF at Pepcore you pay by SEPA bank transfer – we email you our bank details right after your order – or with crypto: USDC or USDT on Polygon, USDC on Base, or Bitcoin. No customer account and no card details are needed.

Frequently asked questions

Scientific references

• Yang SY et al. (2002). Different roles of the IGF-I Ec peptide (MGF) and mature IGF-I in myoblast proliferation and differentiation. FEBS Letters. PubMed
• Hill M et al. (2003). Expression and splicing of the insulin-like growth factor gene in rodent muscle is associated with muscle satellite (stem) cell activation following local tissue damage. The Journal of Physiology. PubMed
• Dluzniewska J et al. (2005). A strong neuroprotective effect of the autonomous C-terminal peptide of IGF-1 Ec (MGF) in brain ischemia. FASEB Journal. PubMed
• Matheny RW Jr et al. (2010). Minireview: Mechano-growth factor: a putative product of IGF-I gene expression involved in tissue repair and regeneration. Endocrinology. PubMed

More studies: PubMed: PEG-MGF

Ready to buy PEG-MGF? Choose your amount above – orders paid before 14:00 CET ship the same day, and shipping is free from €250. For questions about PEG-MGF or a larger research order, write to us at info@pepcore.net.