RUO · ≥99% HPLC
PT-141
≥99% HPLC purity · certificate of analysis on request
€44.00
plus shipping · free from €250
- Same-day dispatch from the Netherlands when paid before 14:00 CET
- ≥99% HPLC – lab reports
- Payment – SEPA bank transfer or crypto
- Discreet, tracked parcel – free shipping from €250
- 10 mg · lyophilized powder
- ≥99% HPLC purity · certificate of analysis on request
- Same-day dispatch from the Netherlands · free shipping from €250
Buy PT-141 at Pepcore: PT-141 as lyophilized powder (10 mg), ≥99% HPLC purity, dispatched from the Netherlands the same business day. PT-141, also called bremelanotide, is a synthetic cyclic peptide built from seven amino acids and classed as a melanocortin-receptor agonist. It is best known in research for how it engages the MC4R and MC3R receptors, and being a ring-shaped (cyclic) peptide is what sets its structure apart.
Buy PT-141: key facts
- Available amounts: 10 mg
- Purity: ≥99% by HPLC – certificate of analysis (HPLC and MS) on request
- Form: Lyophilized powder
- Price: from €44.00
- Dispatch: same business day from the Netherlands when paid before 14:00 CET (Mon–Sat)
- Shipping: tracked across Europe – free from €250
- Payment: SEPA bank transfer or crypto (USDC, USDT, Bitcoin)
PT-141 at a glance
It also has a solid research base, with work exploring how it acts on melanocortin signaling pathways (Molinoff et al., 2003). That makes it a common probe compound in receptor-pharmacology studies.
Research Applications
- Melanocortin-receptor signaling research
- MC4R and MC3R receptor studies
- GPCR structure-activity research
- Central-nervous-system pharmacology models
Supplied as a lyophilized powder for stability.
What is PT-141?
The melanocortin-receptor family is a group of five class A G-protein-coupled receptors (MC1R through MC5R) that engage the endogenous melanocortin peptides derived from proopiomelanocortin (POMC). Each receptor subtype exhibits a distinct tissue-distribution and pharmacology profile, making the melanocortin-receptor family a frequent subject of GPCR pharmacology research and structure-activity research.
PT-141 was engineered as a structural analog of melanotan-II, a cyclic heptapeptide research compound that engages MC1R, MC3R, MC4R, and MC5R. By introducing modifications to the melanotan-II scaffold, PT-141 was designed to reduce MC1R receptor binding affinity while retaining engagement at MC4R and MC3R, two receptor subtypes that are widely expressed across central-nervous-system research tissues.
This receptor-selectivity profile has made PT-141 a research compound of interest for laboratory investigations of MC4R and MC3R receptor pharmacology research, downstream cAMP signaling research, and comparative GPCR pharmacology across the melanocortin-receptor family.
PT-141: structure and specifications
| Peptide Class | Synthetic cyclic heptapeptide research compound (melanocortin-receptor agonist) |
|---|---|
| Sequence | Ac-Nle-cyclo(Asp-His-D-Phe-Arg-Trp-Lys)-OH |
| Residue Count | 7 amino acids (cyclic via lactam bridge) |
| Key Structural Feature | Asp-Lys lactam cyclization with Nle4 and D-Phe7 substitutions |
| Molecular Formula | C₅₀H₆₈N₁₄O₁₀ |
| Molecular Weight | ~1025.2 g/mol |
| CAS Number | 189691-06-3 |
| Research Code | PT-141 |
| Available amounts | 10 mg |
| Form | Lyophilized powder |
| Purity | ≥99% HPLC |
| Storage | −20 °C, dry and protected from light |
| Use | Laboratory research only (RUO) |
PT-141 in laboratory research
MC4R and MC3R Receptor Engagement
PT-141 engages MC4R and MC3R, two melanocortin-receptor subtypes that belong to the class A G-protein-coupled receptor (GPCR) family. Laboratory research studies indicate that PT-141 binds these receptors with nanomolar affinity in cellular research models, with preferential engagement at MC4R relative to MC1R (Molinoff et al., 2003).
Modulation of Cyclic AMP Signaling
Upon receptor binding, PT-141 engages Gαs-coupled signaling at MC4R and MC3R. Adenylyl cyclase activation produces intracellular cyclic AMP accumulation, which is investigated as the primary second-messenger output in melanocortin-receptor signaling research. Downstream, cAMP accumulation modulates protein kinase A (PKA) activity, a frequent subject of GPCR pharmacology research in cellular research models.
Receptor-Selectivity Profile
Structure-activity research has characterized PT-141 as engaging MC4R and MC3R while exhibiting reduced binding affinity at MC1R compared with its parent melanotan-II scaffold. This selectivity profile has positioned PT-141 as a research tool for laboratory investigations of MC4R-specific signaling research and comparative pharmacology across the melanocortin-receptor family.
Downstream Signaling Cascades
Laboratory research studies have characterized melanocortin-receptor activation as modulating downstream signaling cascades including PKA, EPAC, and MAPK research pathways in cellular research models. PT-141 is investigated as a probe compound for examining these downstream signaling networks following MC4R and MC3R engagement (Marchese et al., 2024).
Conclusion
PT-141 represents a synthetic cyclic heptapeptide research compound engineered for selective engagement of MC4R and MC3R within the melanocortin-receptor family. Its receptor-selectivity profile, defined cyclic heptapeptide architecture, and characterized cAMP signaling output make it a valuable investigational laboratory peptide for studies of melanocortin-receptor pharmacology research and class A GPCR signaling research models.
Reconstitution and storage
PT-141 is supplied as a lyophilized powder in a sealed glass vial. In the laboratory it is reconstituted with bacteriostatic water, added slowly down the inside of the vial and swirled gently until dissolved – never shaken. Our peptide calculator works out the concentration for your vial size, and the reconstitution guide explains each step.
Keep unopened vials cool, dry and away from light – frozen at −20 °C for long-term storage. Once reconstituted, keep the solution at 2–8 °C; our peptide stability guide lists typical shelf lives.
Buy PT-141 from Pepcore: shipping and payment
Orders paid before 14:00 CET (Monday–Saturday) leave our Netherlands warehouse the same business day in discreet, tracked packaging. Delivery takes 1–2 business days to the Netherlands and Belgium, 2–7 to Germany, France, Spain, Italy and Luxembourg and 3–8 to the rest of the EU; the UK, Switzerland and Norway take 5–10 days plus customs. Shipping costs from €8.49 and is free from €250 – see our shipping policy.
When you buy PT-141 at Pepcore you pay by SEPA bank transfer – we email you our bank details right after your order – or with crypto: USDC or USDT on Polygon, USDC on Base, or Bitcoin. No customer account and no card details are needed.
Frequently asked questions
What is PT-141?
PT-141, also called bremelanotide, is a synthetic cyclic peptide built from seven amino acids and classed as a melanocortin-receptor agonist. It is supplied as a lyophilized powder for laboratory research use only.
What is PT-141 used for in research?
In research, PT-141 is studied in areas such as: Melanocortin-receptor signaling research, MC4R and MC3R receptor studies and GPCR structure-activity research. Related compounds in our Hair & Skin range include Melanotan 2 and Melanotan 1. Further reading: Oxytocin: how it works and the research.
Where can I buy PT-141 in Europe?
You can buy PT-141 online at Pepcore. We ship from the Netherlands to every European country with tracking, free from €250, and a certificate of analysis is available on request.
How is PT-141 reconstituted?
With bacteriostatic water, added slowly down the inside of the glass rather than onto the powder, then swirled gently, never shaken. Bacteriostatic water is optional when you order: you can add a 3 ml vial (+€4.99) or a 10 ml vial (+€12.99), or leave it out. Use our peptide calculator to work out the concentration for your vial size.
How is PT-141 stored, and how long does shipping take?
Lyophilized PT-141 is kept cool, dry and away from light. Once reconstituted, the solution is refrigerated at 2 to 8 °C, see our peptide stability guide. Orders leave the Netherlands the same or next business day: 1 to 2 business days to the Netherlands and Belgium, 2 to 7 to Germany, France, Spain, Italy and Luxembourg, 3 to 8 to the rest of the EU, free from €250, see shipping.
Is PT-141 intended for human use?
No. PT-141 is sold exclusively for in vitro research and laboratory use. It is not a medicine, food supplement or cosmetic, and it must not be used on humans or animals.
Scientific references
- Molinoff PB et al. (2003). PT-141: a melanocortin agonist for the treatment of sexual dysfunction. Annals of the New York Academy of Sciences. PubMed
- Suzuki S et al. (2024). Melanocortin Receptor Agonist Bremelanotide Induces Cell Death and Growth Inhibition in Glioblastoma Cells via Suppression of Survivin Expression. Anticancer Research. PubMed
- Shinyama H et al. (2003). Regulation of melanocortin-4 receptor signaling: agonist-mediated desensitization and internalization. Endocrinology. PubMed
- Hadley ME, Haskell-Luevano C (1999). The proopiomelanocortin system. Annals of the New York Academy of Sciences. PubMed
- Tao YX (2010). The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology. Endocrine Reviews. PubMed
- Yang Y (2011). Structure, function and regulation of the melanocortin receptors. European Journal of Pharmacology. PubMed
More studies: PubMed: PT-141
Ready to buy PT-141? Choose your amount above – orders paid before 14:00 CET ship the same day, and shipping is free from €250. For questions about PT-141 or a larger research order, write to us at info@pepcore.net.
For laboratory research use only – not for human or veterinary use. All Pepcore products are sold strictly as research materials for in vitro use. They are not medicines, supplements, foods or cosmetics. Sold only to adults aged 18 and over.
