Kisspeptin

Buy Kisspeptin at Pepcore: Kisspeptin as lyophilized powder (10 mg), ≥99% HPLC purity, dispatched from the Netherlands the same business day. Kisspeptin-10 is a short neuropeptide fragment, the 10-amino-acid active piece of the larger kisspeptin protein made by the KISS1 gene. It is best known in research for how it signals through the GPR54 (KISS1R) receptor, and it is studied as a key upstream switch in the reproductive-hormone (HPG) axis.

Buy Kisspeptin: key facts

• Available amounts: 10 mg
• Purity: ≥99% by HPLC – certificate of analysis (HPLC and MS) on request
• Form: Lyophilized powder
• Price: from €69.00
• Dispatch: same business day from the Netherlands when paid before 14:00 CET (Mon–Sat)
• Shipping: tracked across Europe – free from €250
• Payment: SEPA bank transfer or crypto (USDC, USDT, Bitcoin)

Kisspeptin at a glance

It also has a solid research base, with work looking at how it acts on GnRH-producing neurons and downstream hormone signaling (Dhillo et al., 2005, The Journal of Clinical Endocrinology & Metabolism). That makes it a common reference peptide in this field.

Research Applications

• HPG-axis signaling research
• GPR54/KISS1R receptor studies
• GnRH neuron activity research
• Reproductive-hormone regulation models

Supplied as a lyophilized powder for stability.

What is Kisspeptin?

The KISS1 gene was originally identified during research into metastasis-suppression biology, and the kisspeptin family of peptides was named for the research location where it was first characterized. The neuroendocrine role of kisspeptin emerged later, when researchers discovered that inactivating mutations in GPR54, the kisspeptin receptor, produced research-model phenotypes of disrupted pubertal development and impaired reproductive-axis signaling. These findings reshaped the field by identifying kisspeptin as an essential upstream signal for HPG-axis activation.

Subsequent research showed that kisspeptin neurons cluster in distinct hypothalamic nuclei and provide direct, dense innervation to GnRH neurons. Kisspeptin-10, the C-terminal decapeptide fragment, retains full receptor activity and has become the standard research peptide for probing the kisspeptin signaling system in cellular and animal-model studies. Its short sequence and full bioactivity make it an ideal tool compound for receptor-pharmacology studies, electrophysiological characterization of GnRH neuron firing, and species-comparative neuroendocrine signaling research.

Today, kisspeptin research extends beyond classical reproductive-axis biology into metabolic-neuroendocrine coupling, stress-axis interaction studies, and developmental neurobiology research models. Kisspeptin-10 remains the most frequently used kisspeptin research tool for in vitro receptor work and animal-model HPG-axis investigations.

Kisspeptin: structure and specifications

Kisspeptin in laboratory research

GPR54 (KISS1R) Receptor Activation

Kisspeptin-10 binds with high affinity to GPR54, a G-protein-coupled receptor expressed densely on GnRH-producing neurons in hypothalamic research models. Receptor activation engages Gαq/11 signaling, leading to phospholipase-C activation, inositol-trisphosphate generation, and intracellular calcium mobilization. This cascade drives depolarization of GnRH neurons and is the proposed molecular basis for kisspeptin's role in HPG-axis investigation.

GnRH Neuron Modulation

Within neuroendocrine research models, Kisspeptin-10 is studied as the principal upstream signal that initiates GnRH neuron firing patterns. Electrophysiological investigations report increased firing frequency, calcium-spike activity, and pulse-generator coordination in kisspeptin-exposed GnRH neuron preparations, supporting its role as a central neuroendocrine signaling tool compound.

Pituitary Gonadotropin Signaling Research

Through stimulation of GnRH release, Kisspeptin-10 indirectly influences the secretion dynamics of pituitary gonadotropins, including luteinizing hormone and follicle-stimulating hormone. Research-model investigations characterize these downstream signaling effects in animal preparations and in vitro perifusion systems, providing a quantitative framework for studying HPG-axis activation.

Neuroendocrine Network Integration

Kisspeptin neurons receive inputs from multiple regulatory pathways, including metabolic, photoperiodic, and stress-related signals. Kisspeptin-10 is therefore studied not only as a direct GPR54 ligand, but also as a research probe for examining how upstream environmental and metabolic signals are integrated within the kisspeptin-GnRH circuit in neuroendocrine signaling research.

Conclusion

Kisspeptin-10 is the minimal bioactive decapeptide fragment of the kisspeptin neuropeptide family and a primary research tool for studying GPR54 signaling and the upstream control of the HPG axis. Through its activation of GnRH-producing neurons and downstream influence on gonadotropin signaling dynamics, it supports a broad range of neuroendocrine signaling research, reproductive-biology research models, and hypothalamic-neuron investigations in controlled laboratory settings.

Reconstitution and storage

Kisspeptin is supplied as a lyophilized powder in a sealed glass vial. In the laboratory it is reconstituted with bacteriostatic water, added slowly down the inside of the vial and swirled gently until dissolved – never shaken. Our peptide calculator works out the concentration for your vial size, and the reconstitution guide explains each step.

Keep unopened vials cool, dry and away from light – frozen at −20 °C for long-term storage. Once reconstituted, keep the solution at 2–8 °C; our peptide stability guide lists typical shelf lives.

Buy Kisspeptin from Pepcore: shipping and payment

Orders paid before 14:00 CET (Monday–Saturday) leave our Netherlands warehouse the same business day in discreet, tracked packaging. Delivery takes 1–2 business days to the Netherlands and Belgium, 2–7 to Germany, France, Spain, Italy and Luxembourg and 3–8 to the rest of the EU; the UK, Switzerland and Norway take 5–10 days plus customs. Shipping costs from €8.49 and is free from €250 – see our shipping policy.

When you buy Kisspeptin at Pepcore you pay by SEPA bank transfer – we email you our bank details right after your order – or with crypto: USDC or USDT on Polygon, USDC on Base, or Bitcoin. No customer account and no card details are needed.

Frequently asked questions

Scientific references

• Dhillo WS et al. (2005). Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males. The Journal of Clinical Endocrinology and Metabolism. PubMed
• de Roux N et al. (2003). Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54. Proceedings of the National Academy of Sciences of the United States of America. PubMed
• Seminara SB et al. (2003). The GPR54 gene as a regulator of puberty. The New England Journal of Medicine. PubMed
• Messager S et al. (2005). Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54. Proceedings of the National Academy of Sciences of the United States of America. PubMed
• Pinilla L et al. (2012). Kisspeptins and reproduction: physiological roles and regulatory mechanisms. Physiological Reviews. PubMed
• Roa J et al. (2008). New frontiers in kisspeptin/GPR54 physiology as fundamental gatekeepers of reproductive function. Frontiers in Neuroendocrinology. PubMed

More studies: PubMed: Kisspeptin

Ready to buy Kisspeptin? Choose your amount above – orders paid before 14:00 CET ship the same day, and shipping is free from €250. For questions about Kisspeptin or a larger research order, write to us at info@pepcore.net.